Table 1 Baseline characteristics according to endocrine resistance in patients who received adjuvant endocrine therapy.

From: Primary endocrine resistance of ER+ breast cancer with ESR1 mutations interrogated by droplet digital PCR

 

Primary endocrine resistance

(N = 28)

Secondary endocrine resistance

(N = 46)

Endocrine Sensitive

(N = 24)

Total

(N = 98)

P value

Age (median, range)

45 (28–77)

44 (30–74)

48 (23–75)

45 (23–77)

0.973

Histologic type

    

0.789a

 IDC

23 (82.1%)

42 (91.3%)

21 (87.5%)

86 (87.8%)

 

 ILC

2 (7.1%)

2 (4.3%)

1 (4.2%)

5 (5.1%)

 

 Others

3 (10.7%)

2 (4.3%)

2 (8.3%)

7 (7.1%)

 

HGb

    

0.493a

 1 or 2

21 (84.0%)

37 (86.0%)

21 (95.5%)

79 (87.8%)

 

 3

4 (16.0%)

6 (14.0%)

1 (4.5%)

11 (12.2%)

 

LVIb

    

0.316

 No

14 (66.7%)

27 (73.0%)

12 (92.3%)

53 (74.6%)

 

 Yes

7 (33.3%)

10 (27.0%)

1 (7.7%)

18 (25.4%)

 

T stage

    

0.011a

 1

8 (28.6%)

23 (50.0%)

13 (54.2%)

44 (44.9%)

 

 2

15 (53.6%)

23 (50.0%)

11 (45.8%)

49 (50.0%)

 

 3

5 (17.9%)

0

0

5 (5.1%)

 

N stage

    

0.336a

 0

11 (39.3%)

20 (43.5%)

11 (45.8%)

42 (42.9%)

 

 1

8 (28.6%)

16 (34.8%)

9 (37.5%)

33 (33.7%)

 

 2

3 (10.7%)

4 (8.7%)

4 (16.7%)

11 (11.2%)

 

 3

6 (21.4%)

6 (13.0%)

0

12 (12.2%)

 

Stage

    

0.424

 1

6 (21.4%)

14 (30.4%)

10 (41.7%)

30 (30.6%)

 

 2

12 (42.9%)

22 (47.8%)

10 (41.7%)

44 (44.9%)

 

 3

10 (35.7%)

10 (21.7%)

4 (16.7%)

24 (24.5%)

 

Breast surgery

    

0.083

 BCS

6 (21.4%)

18 (39.1%)

12 (50.0%)

36 (36.7%)

 

 TM

22 (78.6%)

28 (60.9%)

12 (50.0%)

62 (63.3%)

 

Axillary surgery

    

0.142

 SLNB

9 (26.5%)

8 (17.4%)

9 (37.5%)

26 (26.5%)

 

 ALND

19 (67.9%)

38 (82.6%)

15 (62.5%)

72 (73.5%)

 

Adjuvant chemotherapy

    

0.426

 No

4 (14.3%)

10 (21.7%)

7 (29.2%)

21 (21.4%)

 

 Yes

24 (85.7%)

36 (78.3%)

17 (70.8%)

77 (78.6%)

 

Adjuvant endocrine

    

0.466

 Tamoxifen

17 (60.7%)

30 (65.2%)

12 (50.0%)

59 (60.2%)

 

 AI

11 (39.3%)

16 (34.8%)

12 (50.0%)

39 (39.8%)

 

Adjuvant radiotherapy

    

0.402

 No

8 (28.6%)

20 (43.5%)

8 (33.3%)

36 (36.7%)

 

 Yes

20 (71.4%)

26 (56.5%)

16 (66.7%)

62 (63.3%)

 
  1. IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, HG histologic grade, LVI lymphovascular invasion, BCS breast-conserving surgery, TM total mastectomy, SLNB sentinel lymph node biopsy, ALND axillary lymph node dissection, AI aromatase inhibitor.
  2. aP values were obtained using Fisher’s exact test.
  3. bMissing values.