Table 1 Patient characteristics in the NCCTG N9831 and NeoALTTO.

From: Adaptive immune signature in HER2-positive breast cancer in NCCTG (Alliance) N9831 and NeoALTTO trials

 

N9831 (N = 1268)

NeoALTTO (N = 244)

Total (N = 1512)

P valuea

Age (years)

   

0.1968

 Mean (SD)

50.0 (±10.6)

48.9 (±11.3)

49.9 (±10.7)

 

 Median

50.0

49.0

50.0

 

 Range

(22.0–80.0)

(23.0–79.0)

(22.0–80.0)

 

Tumor size (cm)

   

<0.0001

 Mean (SD)

2.9 (±1.8)

10.8 (±15.4)

4.2 (±7.0)

 

 Median

2.5

4.2

2.6

 

 Range

(0.1–15.0)

(2.1–90.0)

(0.1–90.0)

 

Lymph node status

   

<0.0001

 N0 or N1

745 (58.8%)

206 (84.4%)

951 (62.9%)

 

 N2 or N3

523 (41.2%)

38 (15.6%)

561 (37.1%)

 

Tumor grade

   

<0.0001

 Missing

15

122

137

 

 Grade 1

23 (1.8%)

11 (9.0%)

34 (2.5%)

 

 Grade 2

324 (25.9%)

57 (46.7%)

381 (27.7%)

 

 Grade 3

906 (72.3%)

54 (44.3%)

960 (69.8%)

 

ER status

   

0.2440

 Negative

598 (47.2%)

125 (51.2%)

723 (47.8%)

 

 Positive

670 (52.8%)

119 (48.8%)

789 (52.2%)

 

ARMb

   

0.3635

 A or 1

445 (35.1%)

85 (34.8%)

530 (35.1%)

 

 B or 2

449 (35.4%)

77 (31.6%)

526 (34.8%)

 

 C or 3

374 (29.5%)

82 (33.6%)

456 (30.2%)

 
  1. aWilcoxon rank-sum test was used for continuous variables and Chi-square test was used for categorical variables.
  2. bArm A, B, and C in NCCTG N9831 and Arm 1, 2, and 3 in NeoALTTO trial.