Table 2 Treatment-related adverse events of all grades reported in >20% and of grade 3 or 4 reported in >5% of patients by age.
TRAE1, n (%) | SG | TPC | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
<65 years (n = 209) | ≥65 years (n = 49) | <65 years (n = 176) | ≥65 years (n = 48) | |||||||||
All grades | Grade 3 | Grade 4 | All grades | Grade 3 | Grade 4 | All grades | Grade 3 | Grade 4 | All grades | Grade 3 | Grade 4 | |
Hematologic | ||||||||||||
Neutropenia2 | 134 (64) | 76 (36) | 34 (16) | 29 (59) | 12 (24) | 10 (20) | 75 (43) | 30 (17) | 25 (14) | 21 (44) | 15 (31) | 4 (8) |
Anemia3 | 63 (30) | 13 (6) | 0 | 26 (53) | 7 (14) | 0 | 40 (23) | 8 (5) | 0 | 14 (29) | 3 (6) | 0 |
Leukopenia4 | 33 (16) | 19 (9) | 2 (1) | 8 (16) | 4 (8) | 1 (2) | 18 (10) | 8 (5) | 2 (1) | 7 (15) | 2 (4) | 0 |
Febrile neutropenia | 11 (5) | 10 (5) | 1 (<1) | 4 (8) | 2 (4) | 2 (4) | 5 (3) | 4 (2) | 1 (1) | 0 | 0 | 0 |
Gastrointestinal | ||||||||||||
Diarrhea | 121 (58) | 22 (11) | 0 | 32 (65) | 5 (10) | 0 | 20 (11) | 1 (1) | 0 | 7 (15) | 0 | 0 |
Nausea | 123 (59) | 6 (3) | 1 (<1) | 24 (49) | 0 | 0 | 48 (27) | 0 | 0 | 11 (23) | 1 (2) | 0 |
Constipation | 32 (15) | 0 | 0 | 12 (24) | 0 | 0 | 27 (15) | 0 | 0 | 5 (10) | 0 | 0 |
Vomiting | 63 (30) | 2 (1) | 1 (<1) | 12 (24) | 0 | 0 | 20 (11) | 0 | 0 | 3 (6) | 1 (2) | 0 |
Other | ||||||||||||
Fatigue | 91 (44) | 6 (3) | 0 | 24 (49) | 2 (4) | 0 | 49 (28) | 10 (6) | 0 | 19 (40) | 2 (4) | 0 |
Alopecia | 101 (48) | 0 | 0 | 18 (37) | 0 | 0 | 27 (15) | 0 | 0 | 8 (17) | 0 | 0 |
Decreased appetite | 40 (19) | 2 (1) | 0 | 11 (22) | 2 (4) | 0 | 25 (14) | 1 (1) | 0 | 7 (15) | 0 | 0 |
