Table 2 Estrogen receptor and immune and proliferation-related signatures in younger and older breast cancer patients.

From: Molecular differences between younger versus older ER-positive and HER2-negative breast cancers

  

Signature

log2 fold change

Mean in younger

Mean in older

P value

FDR

TCGA

Estrogen receptor

ERS Neg Symmans

0.52

0.26

−0.26

<0.001

<0.001

ERS Pos Symmans

−0.21

0.09

0.30

<0.001

<0.001

ERS luminal

−0.17

0.14

0.31

<0.001

<0.001

ERS

−0.14

0.20

0.34

0.004

0.005

Immune

B cell

0.34

0.25

−0.09

<0.001

<0.001

T cell

0.35

0.19

−0.16

<0.001

<0.001

Mast cell

0.25

0.29

0.04

0.003

0.004

TIS

0.26

0.09

−0.18

0.002

0.003

Dendritic cell

0.15

−0.04

−0.19

0.13

0.22

Proliferation

MKS

0.07

−0.31

−0.37

0.46

0.46

Cohort-A

Estrogen receptor

ERS Neg Symmans

0.33

0.22

−0.11

<0.001

<0.001

ERS Pos Symmans

−0.31

−0.21

0.10

<0.001

<0.001

ERS luminal

−0.13

−0.09

0.04

0.08

0.14

ERS

−0.07

−0.05

0.02

0.21

0.31

Immune

B cell

0.20

0.13

−0.06

0.001

0.004

Mast cell

0.16

0.11

−0.05

0.002

0.004

T cell

0.13

0.09

−0.04

0.08

0.14

TIS

0.04

0.02

−0.01

0.61

0.66

Dendritic cell

−0.03

−0.02

0.01

0.59

0.66

Proliferation

MKS

0.03

0.02

−0.01

0.71

0.71

Cohort-B

Estrogen receptor

ERS Neg Symmans

0.27

0.20

−0.07

<0.001

0.002

ERS Pos Symmans

−0.22

−0.16

0.06

0.002

0.005

ERS Luminal

0.01

0.01

0.00

0.95

0.95

ERS

−0.10

−0.07

0.03

0.18

0.25

Immune

B cell

0.51

0.38

−0.14

<0.001

<0.001

T cell

0.41

0.30

−0.11

<0.001

<0.001

TIS

0.20

0.15

−0.05

0.02

0.03

Dendritic cell

0.14

0.10

−0.04

0.02

0.04

Mast cell

0.01

0.01

0.00

0.73

0.88

Proliferation

MKS

−0.01

0.00

0.00

0.88

0.95

METABRIC

Estrogen receptor

ERS Neg Symmans

0.63

0.51

−0.11

<0.001

<0.001

ERS Pos Symmans

−0.29

−0.24

0.05

<0.001

0.001

ERS luminal

−0.21

−0.18

0.04

0.02

0.03

ERS

−0.44

−0.36

0.08

<0.001

<0.001

Immune

B cell

0.22

0.18

−0.04

<0.001

<0.001

T cell

0.20

0.17

−0.04

0.004

0.009

TIS

0.09

0.08

−0.02

0.28

0.28

Dendritic cell

0.06

0.05

−0.01

0.19

0.22

Mast cell

0.21

0.18

−0.04

0.01

0.01

Proliferation

MKS

−0.11

−0.09

0.02

0.20

0.22

SCAN-B

Estrogen receptor

ERS Neg Symmans

0.33

0.27

−0.06

<0.001

<0.001

ERS Pos Symmans

−0.09

−0.07

0.02

0.06

0.10

ERS luminal

−0.01

−0.01

0.00

0.69

0.69

ERS

−0.09

−0.08

0.02

0.06

0.10

Immune

B cell

0.31

0.25

−0.06

<0.001

<0.001

T cell

0.25

0.20

−0.05

<0.001

<0.001

TIS

0.13

0.11

−0.02

0.16

0.25

Dendritic cell

−0.22

−0.18

0.04

<0.001

0.002

Mast cell

0.09

0.07

−0.02

0.25

0.33

Proliferation

MKS

0.08

0.07

−0.01

0.32

0.38

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