Fig. 2: Molecular landscape of the FUSCCTNBC-mammography cohort.
From: Calcifications in triple-negative breast cancer: Molecular features and treatment strategies
a Three hundred and twelve TNBC samples annotated with clinical and molecular features. Samples are ordered by calcification status. b Somatic mutations of the top mutated genes. Genes are ordered by the total mutation frequencies. c Copy number alteration of cancer-related genes. Only amplifications (GISTIC + 2) and deep deletions (GISTIC -2) are presented. d Gene-level mutation frequencies across different calcification groups. “**” denotes a P-value of < 0.01. e Region-level SCNA frequency across different calcification groups. “**” denotes a P-value of < 0.01 and “*” denotes a P-values of < 0.05. Logistics regression models using the binomial family were performed to obtain P values for the comparison analyses of mutations and SCNAs between different calcification groups.
