Fig. 7: Proposed model for CXorf56 protein in the regulation of DNA repair pathway choice.
From: Inhibition of CXorf56 promotes PARP inhibitor-induced cytotoxicity in triple-negative breast cancer
A Upregulated CXorf56 protein naturally binds to Ku70, which blocks the binding of Ku70 with the damaged DNA, inducing a selection of HR over NHEJ by competitive recruitment of HR regulators for the repair of DSBs. B Without the binding of CXorf56 protein with Ku70, Ku70 is recruited into chromatin at DSB sites and activates the NHEJ pathway by further forming the phospho-DNA-PKcs, XRCC4, and LIG4 complex.
