Fig. 2: TME of TNBC, compared to ER+/HER2- breast cancer, is enriched for pro-metastatic markers, except for microvascular density. | npj Breast Cancer

Fig. 2: TME of TNBC, compared to ER+/HER2- breast cancer, is enriched for pro-metastatic markers, except for microvascular density.

From: Racial disparity in tumor microenvironment and distant recurrence in residual breast cancer after neoadjuvant chemotherapy

Fig. 2

a Representative images for SOX9-high cells (yellow arrows) and -low cells (white arrowheads). Scale bar, 10 µm. b TMEM doorway score (p = 0.004). c Macrophage density (p = 0.0002). d Cancer stem cells (p = 0.0002). e Microvascular density (p = 0.44) levels in patients with ER+/HER2- breast cancer (n = 91) vs TNBC (n = 59). ER+ Estrogen receptor positive, TNBC Triple negative breast cancer, TME Tumor microenvironment. Mann-Whitney U-test is used for comparison between two-independent groups and box and whisker diagram is used for plotting the data (b–e). Box represents median value, lower and upper quartile values. Whiskers show minimum and maximum data values. Outliers are single data points that are more than 1.5 times of upper or lower quartiles. ns: not statistically significant, p > 0.05, *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.

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