Fig. 5: Summary of racial disparity in pro-metastatic TME of residual ER+/HER2- breast cancer after neoadjuvant chemotherapy (NAC). | npj Breast Cancer

Fig. 5: Summary of racial disparity in pro-metastatic TME of residual ER+/HER2- breast cancer after neoadjuvant chemotherapy (NAC).

From: Racial disparity in tumor microenvironment and distant recurrence in residual breast cancer after neoadjuvant chemotherapy

Fig. 5

Black patients with residual ER+/HER2- breast cancer after NAC have higher numbers of TMEM doorways and macrophages in their tumor microenvironment compared to white patients. TMEM doorways are localized, transient vascular openings formed by Mena expressing tumor cell, perivascular macrophage, and endothelial cell. Increased permeability around TMEM doorways helps cancer cells to intravasate and disseminate to other organs. Higher TMEM doorway score can be one of the mechanisms of inferior outcome and distant recurrence free survival in Black vs white patients with residual ER+/HER2- breast cancer. This original clipart was created with BioRender.com.

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