Fig. 2: Intra-patient heterogeneity of the HGP. | npj Breast Cancer

Fig. 2: Intra-patient heterogeneity of the HGP.

From: Histopathological growth patterns and tumor-infiltrating lymphocytes in breast cancer liver metastases

Fig. 2

a Intra-metastasis inter-slide heterogeneity was observed in 29 (22%) patients in the surgical cohort. The proportion (%) of each HGP is given on the y axis. Each column represents a slide, and each box represents a patient. b Association between the number of slides scored (y axis) and the inter-slide heterogeneity (x axis). The significance of the association is assessed by a Wilcoxon–Mann–Whitney test between heterogeneous and non-heterogeneous (p value < 0.001). c HGP category in the five patients (OLi-35, OLi-2, OLi-67, OLi-81, OLi-23; y axis) who underwent two surgical resections of LM. The time (x axis) reflects the interval between the two liver surgeries. d Percentage of desmoplastic component (y axis) in the surgically resected LM of these 5 patients. In patients OLi-2, OLi-81, OLi-23, OLi-67, and OLi-35, HGP was assessed in 1, 2, 4, 2, and 8 slides of the first liver resection and 3, 4, 4, 3, and 1 of the second liver resection, respectively. Blue dot= ‘any d-HGP’ LM; red dot= ‘pure r-HGP’ LM. Blue= Desmoplastic; red= Replacement, green= Pushing. HGP Histopathological Growth Patterns, d-HGP desmoplastic, r-HGP replacement.

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