Table 2 Relation between HER2 classification of tumor lesions and anatomic response measurements.

From: Molecular imaging predicts lack of T-DM1 response in advanced HER2-positive breast cancer (final results of ZEPHIR trial)

 

Classification

n lesions

Anatomic lesion response after three T-DM1 cycles

PPV

NPV

 

R

NR

  

HER2 PET/CT

+

172

123

49

72%1

 

−

93

18

75

 

81%2

  1. Exact 95% confidence intervals as follows: 1: 64–78%, 2: 71–88%.
  2. n number, HER2+ HER2-positive lesions (class 3 and 4), HER2- HER2-negative lesions (class 1 and 2), R anatomically responding lesions, NR anatomically non-responding lesions.
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