Table 1 Participant baseline characteristics in four cohorts

From: Deep learning radiomics based prediction of axillary lymph node metastasis in breast cancer

Characteristic

TC (n = 621)

EVC1 (n = 112)

EVC2 (n = 87)

EVC3 (n = 63)

Age (years)

54.50 ± 11.51

55.19 ± 10.65

53.93 ± 11.94

54.78 ± 9.83

Ultrasound size (cm)

2.24 ± 1.06

2.26 ± 1.12

2.17 ± 1.21

2.22 ± 0.98

BMI

 <25

237 (38.16%)

36 (32.14%)

26 (29.89%)

21 (33.33%)

 25–30

172 (27.70%)

36 (32.14%)

27 (31.03%)

22 (34.92%)

 >30

174 (28.02%)

35 (31.25%)

32 (36.78%)

14 (22.22%)

Not appliable

38 (6.12%)

5 (4.46%)

2 (2.30%)

6 (9.52%)

BI-RADS category

 4A

172 (27.70%)

18 (16.07%)

6 (6.90%)

13 (20.63%)

 4B

144 (23.19%)

35 (31.25%)

12 (13.79%)

21 (33.33%)

 4C

133 (21.42%)

8 (7.14%)

12 (13.79%)

18 (28.57%)

 5

172 (27.70%)

51 (45.54%)

57 (65.52%)

11 (17.46%)

Tumor location

 UOQ

130 (20.93%)

21 (18.75%)

25 (28.74%)

31 (49.21%)

 LOQ

61 (9.82%)

12 (10.71%)

6 (6.90%)

12 (19.05%)

 UIQ

163 (26.25%)

38 (33.93%)

25 (28.74%)

6 (9.52%)

 LIQ

66 (10.63%)

26 (23.21%)

13 (14.94%)

13 (20.63%)

 Central

201 (32.37%)

15 (13.39%)

18 (20.69%)

1 (1.59%)

Nuclear grade

 I

96 (15.46%)

5 (4.46%)

13 (14.94%)

10 (15.87%)

 II

298 (47.99%)

67 (59.82%)

49 (56.32%)

37 (58.73%)

 III

227 (36.55%)

40 (35.71%)

25 (28.74%)

16 (25.40%)

Tumor classification

 Noninvasive carcinoma

59 (9.51%)

4 (3.57%)

7 (8.05%)

2 (3.17%)

Invasive carcinoma

 NST

489 (78.74%)

97 (86.61%)

71 (81.61%)

60 (95.24%)

 ST

43 (6.92%)

8 (7.14%)

6 (6.90%)

0 (0.00%)

 Rare carcinoma

30 (4.83%)

3 (2.68%)

3 (3.45%)

1 (1.59%)

ER

 Positive

451 (72.62%)

83 (74.11%)

64 (73.56%)

35 (55.56%)

 Negative

170 (27.38%)

29 (25.89%)

23 (26.44%)

28 (44.44%)

PR

 Positive

402 (64.73%)

78 (69.64%)

52 (59.77%)

42 (66.67%)

 Negative

219 (35.27%)

34 (30.36%)

35 (40.23%)

21 (33.33%)

HER2

 Positive

520 (83.73%)

34 (30.36%)

66 (75.86%)

48 (76.19%)

 Negative

101 (16.26%)

78 (69.64%)

21 (24.14%)

15 (23.81%)

Ki-67

 Positive

514 (82.77%)

90 (80.36%)

66 (75.86%)

47 (74.60%)

 Negative

107 (17.23%)

22 (19.64%)

21 (24.14%)

16 (25.40%)

Surrogate subtype

 Luminal A-like

248 (39.94%)

16 (14.29%)

6 (6.90%)

1 (1.59%)

 Luminal B-like

216 (34.78%)

71 (63.39%)

58 (66.67%)

39 (61.90%)

 HER2-overexpression

127 (20.45%)

11 (9.82%)

20 (22.99%)

15 (23.81%)

 Triple negative

30 (4.83%)

14 (12.50%)

3 (3.45%)

8 (12.70%)

US-ALN

 Suspicious

242 (38.97%)

37 (33.04%)

44 (50.57%)

22 (34.92%)

 Non-suspicious

379 (61.03%)

75 (66.96%)

43 (49.43%)

41 (65.08%)

ALN metastasis

 Positive

215 (34.62%)

45 (40.18%)

35 (40.23%)

32 (50.79%)

 Negative

406 (65.38%)

67 (59.82%)

52 (59.77%)

31 (49.21%)

  1. TC training cohort, EVC external validation cohort, BMI body mass index, UOQ upper outer quadrant, LOQ lower outer quadrant, UIQ upper inner quadrant, LIQ lower inner quadrant, NST no special type, ST special type, ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor-2, US-ALN axillary lymph nodes status reported by axillary ultrasound.