Fig. 2: Differentiation subsets of immune cells in BC patients and HD. | npj Breast Cancer

Fig. 2: Differentiation subsets of immune cells in BC patients and HD.

From: Peripheral immune cells in metastatic breast cancer patients display a systemic immunosuppressed signature consistent with chronic inflammation

Fig. 2

a–d Adaptive immune cells (a) CD4+ T (b) CD8+ T (c) B-cells (d) Effect of previous chemotherapy and CDK inhibitors on phenotype of adaptive immune cells in BC patients. Heatmap represents relative median of each cell subset across HD and different patient groups. e–h Innate immune cells (e) Monocytes (f) mDCs (g-h) NK cells. Two groups were compared by Wilcoxon Mann-Whitney Rank Sum Test. More than two groups were compared by kruskal wallis test, followed by pair-wise comparisons using Wilcoxon Mann–Whitney Rank Sum Test with HD as a reference group. p.adj < 0.05 was considered statistically significant. *p.adj < 0.05, **p.adj < 0.01, ***p.adj < 0.001, ****p.adj < 0.0001. BC: n = 104. HD: n = 20. Box plots show median (center line), 25th and 75th percentiles (box), data within 1.5 IQR (whiskers), and outliers (dots). Abbreviations: CM central memory, EM effector memory, TEMRA effector memory re-expressing CD45RA, SM switched memory, NSM non-switched memory, DN double negative, Mo-MDSCs Monocytic myeloid derived suppressor cells.

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