Fig. 3: Phenotypic characterization of T cells in BC patients and HD. | npj Breast Cancer

Fig. 3: Phenotypic characterization of T cells in BC patients and HD.

From: Peripheral immune cells in metastatic breast cancer patients display a systemic immunosuppressed signature consistent with chronic inflammation

Fig. 3

Expression of immune checkpoint receptors (a) and functional/phenotypic markers (b) in CD4+ and CD8+ T cells. c Abundance of Th1/Th2/Th17 subsets in CD4+ T cells. d Effect of previous chemotherapy and CDK inhibitors on phenotype of T cells in BC patients. Heatmap represents relative median of each cell subset across HD and different patient groups. Two groups were compared by Wilcoxon Mann–Whitney Rank Sum Test. More than two groups were compared by Kruskal–Wallis test, followed by pair-wise comparisons using Wilcoxon Mann-Whitney Rank Sum Test using HD as a reference group. *p.adj < 0.05, **p.adj < 0.01, ***p.adj < 0.001, ****p.adj < 0.0001. BC: n = 104. HD: n = 20. Box plots show median (center line), 25th and 75th percentiles (box), data within 1.5 IQR (whiskers), and outliers (dots). Abbreviations: NKT natural killer T cells.

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