Fig. 7: IFNγ production correlates with CD4+ T cell clusters identified by unsupervised analysis. | npj Breast Cancer

Fig. 7: IFNγ production correlates with CD4+ T cell clusters identified by unsupervised analysis.

From: Peripheral immune cells in metastatic breast cancer patients display a systemic immunosuppressed signature consistent with chronic inflammation

Fig. 7

PBMCs from BC (n = 95) patients were stimulated by CD3/CD28 beads and IFNγ production was determined by flow cytometry. a Spearman rank correlation of CD4+ T cell clusters (shown in Fig. 4) with IFNγ production by CD4+ T cells. Only T cell clusters with a significant correlation are shown. FDR-adjusted p-values are shown. b Heat map (hierarchical clustering) representing relative abundance of the 13 CD4+ T clusters in IFNhigh and IFNlow BC patients. Groups were compared with Fisher’s exact test.

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