Fig. 3: PALOMA-2 subtype correlations and PFS by subtype. | npj Breast Cancer

Fig. 3: PALOMA-2 subtype correlations and PFS by subtype.

From: Effect of cross-platform gene-expression, computational methods on breast cancer subtyping in PALOMA-2 and PALLET studies

Fig. 3

a Plot of the largest two correlations between sample expression data and ruoProsigna subtype centroids. The solid line is the equal line, and the dashed line is 0.1 from the equal line. Each symbol is a sample. Symbol “AB” means the largest correlation coefficient is with LumA and the second largest correlation is with LumB. The same pattern follows for the remaining symbol combinations. b PFS in the palbociclib plus letrozole group between patients with clear-defined subtypes (solid lines) versus patients with discord subtypes (dashed lines) based on agreement between the HTG-AIMS and ruoProsigna-PAM50 methods. In the figure on the left, the subtype is based on AIMS; in the figure on the right, the subtype is based on PAM50. LET letrozole, NonLum nonluminal, PAL palbociclib.

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