Table 1 Overall immune cell density and distribution
TNBC (n = 18) | HR + HER2-BC (n = 14) | pa | pb | |
|---|---|---|---|---|
Fields number, mean ± SD | 129.4 ± 116.2 | 75.4 ± 53.3 | 0.090 | |
Mean ROI, mm2, mean ± SD | ||||
Tumor | 28.3 ± 30.1 | 10.6 ± 11.8 | 0.032 | |
Stroma | 48.3 ± 38.6 | 34.5 ± 18.8 | 0.193 | |
Total IC density in stroma, per mm2, mean ± SD (IC composition %) | 6368.8 ± 3261.3 (100.0) | 7561.4 ± 3878.8 (100.0) | 0.442 | |
CD20 | 1340.7 ± 1326.9 (21.1) | 2754.9 ± 2506.3 (35.5) | 0.180 | <0.001 |
CD8 | 1694.3 ± 1053.8 (26.6) | 1311.6 ± 679.3 (16.9) | 0.377 | |
CD4 | 3333.8 ± 1263.5 (52.3) | 3694.9 ± 1693.0 (47.6) | 0.866 | |
FOXP3+ (% among CD4) | 129.7 ± 69.6 (3.9) | 103.3 ± 119.5 (3.0) | 0.059 | 0.036 |
FOXP3− (% among CD4) | 3204.0 ± 1237.8 (96.1) | 3391.6 ± 1610.9 (97.0) | 0.808 | |
Total IC density, per mm2, mean ± SD (IC composition %) | 1364.4 ± 1384.6 | 1578.7 ± 2180.0 | 0.722 | |
CD20 | 166.0 ± 201.0 (12.2) | 638.4 ± 1163.8 (40.4) | 0.319 | <0.001 |
CD8 | 731.6 ± 885.8 (56.6) | 481.0 ± 510.3 (30.5) | 1.000 | |
CD4 | 466.7 ± 517.8 (34.2) | 459.3 ± 724.1 (29.1) | 0.722 | |
FOXP3+ (% among CD4) | 32.5 ± 43.8 (7.0) | 19.3 ± 25.8 (4.2) | 0.587 | 0.073 |
FOXP3− (% among CD4) | 434.2 ± 482.3 (93.0) | 440.0 ± 724.8 (95.8) | 0.779 | |
