Fig. 4: Correlational analysis and prognostic implications of CXCL9 and CXCR3. | npj Breast Cancer

Fig. 4: Correlational analysis and prognostic implications of CXCL9 and CXCR3.

From: Spatial proximity of CD8+ T cells to tumor cells predicts neoadjuvant therapy efficacy in breast cancer

Fig. 4

A Positive correlation between CXCL9 expression and the percentage of CD8 + T cells within 20 μm of tumor cells (N20-CD8 + T cells). B Positive correlation between CXCR3 expression and the percentage of N20-CD8 + T cells. C Positive correlation between CXCL9 expression and the percentage of intraepithelial CD3 + T cells. D Positive correlation between CXCR3 expression and intraepithelial CD3 + T cells. E Positive correlation between CXCL9 and CXCR3 expression levels. Pearson correlation coefficients and p values are indicated in each panel. F, G Neither CXCL9 nor CXCR3 showed prognostic significance for disease outcomes. H Representative immunohistochemical (IHC) staining image for CXCL9 and CXCR3. In continuously sliced sections, CXCL9 was expressed in cancer cells and the interface area between cancer cells and immune cells, and CXCR3 was expressed mainly in immune cells in the area neighboring to cancer cells. IHC Immunohistochemistry, N20-CD8+T the average number of CD8+ T cells within a 20 µm radius of tumor cells; CD3+T CD3 positive T cells.

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