Fig. 3: Immune gene signatures (rows) by TP53 mutation type (columns), with each cell representing the expression of the corresponding signature in samples with the corresponding TP53 mutation type. | npj Breast Cancer

Fig. 3: Immune gene signatures (rows) by TP53 mutation type (columns), with each cell representing the expression of the corresponding signature in samples with the corresponding TP53 mutation type.

From: Prognostic and molecular multi-platform analysis of CALGB 40603 (Alliance) and public triple-negative breast cancer datasets

Fig. 3

Annotations represent the significance of a one-sided Wilcoxon rank-sum test comparing the immune signature expression of samples with the corresponding TP53 mutation type vs. the immune signature expression of normal samples, adjusted for multiple tests (*FDR-adj p ≤ 0.05, **FDR-adj p ≤ 0.01). The immune signatures shown in the heatmap represent those with FDR-adj p < 0.05 for at least one recurrent TP53 missense mutation and FDR-adj p ≥ 0.05 for TP53 nonsense mutations. Rows are hierarchically clustered.

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