Fig. 2: Frequency of hemizygous PTEN alterations in ER+ BC using METABRIC and TCGA datasets. | npj Breast Cancer

Fig. 2: Frequency of hemizygous PTEN alterations in ER+ BC using METABRIC and TCGA datasets.

From: The interplay between FOXO3 and FOXM1 influences sensitivity to AKT inhibition in PIK3CA and PIK3CA/PTEN altered estrogen receptor positive breast cancer

Fig. 2

A Prevalence of PTEN heterozygous loss in TCGA and Metabric both in the full breast cancer cohort and co-occurring within the ER+/HER2- breast cancer as above are shown as bar graphs. B Oncoprints for co-occurring PTEN heterozygous loss in PIK3CA mutated biopsies are shown in ER+/HER2- in TCGA and Metabric cohorts (C) Pie charts show the proportion of different PIK3CA mutations in the PTENalt (homozygous loss, missense mutations and truncations) ER+/HER2- breast tumours in Metabric (n = 14) and TCGA (n = 33) and PTENhemidel (hemizygous loss) in Metabric n = 93 and TCGA n = 47. Plots were generated in R version 4.3.2 with the package ‘plotly’.

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