Table 1 Baseline characteristics (categorial) of non-pregnant vs. pregnant BC patients
From: Effects of pregnancy on breast cancer immunology: immune biomarker and TIL quantification
Parameter | Category | Non-pregnant N = 125, N (%) | Pregnant N = 125, N (%) | Overall N = 250, N (%) | P value |
|---|---|---|---|---|---|
Age at diagnosis, years | 18–29 | 5 (4.0) | 14 (11.2) | 19 (7.6) | <0.001 |
30–34 | 32 (25.6) | 56 (44.8) | 88 (35.2) | ||
35–39 | 51 (40.8) | 44 (35.2) | 95 (38.0) | ||
≥40 | 37 (29.6) | 11 (8.8) | 48 (19.2) | ||
HR status combined** | ER and PR negative | 50 (40.0) | 52 (41.6) | 102 (40.8) | 0.898 |
ER and/or PR positive | 75 (60.0) | 73 (58.4) | 148 (59.2) | ||
HER2 status** | Negative | 98 (81.0) | 95 (78.5) | 193 (79.8) | 0.749 |
Positive | 23 (19.0) | 26 (21.5) | 49 (20.2) | ||
Missing | 4 | 4 | 8 | ||
Biological subtype** | TNBC | 44 (35.2) | 45 (36.0) | 89 (35.6) | 0.989 |
HER2 + /HR− | 6 (4.8) | 7 (5.6) | 13 (5.2) | ||
HER2 + /HR+ | 19 (15.2) | 19 (15.2) | 38 (15.2) | ||
HER2-/HR+ | 56 (44.8) | 54 (43.2) | 110 (44.0) | ||
Histological tumor type** | Ductal or ductal-lobular invasive | 101 (80.8) | 111 (90.2) | 212 (85.5) | 0.058 |
Lobular invasive | 9 (7.2) | 7 (5.7) | 16 (6.5) | ||
Other | 15 (12.0) | 5 (4.1) | 20 (8.1) | ||
Missing | 0 | 2 | 2 | ||
Tumor grading** | G1 | 1 (0.8) | 1 (0.8) | 2 (0.8) | 0.991 |
G2 | 40 (32.0) | 39 (31.2) | 79 (31.6) | ||
G3 | 84 (67.2) | 85 (68.0) | 169 (67.6) | ||
T stage* | T1 | 38 (30.4) | 38 (30.4) | 76 (30.4) | 0.947 |
T2 | 65 (52.0) | 63 (50.4) | 128 (51.2) | ||
T3 | 17 (13.6) | 17 (13.6) | 34 (13.6) | ||
T4 | 5 (4.0) | 7 (5.6) | 12 (4.8) | ||
N stage* | N0 | 0 (0.0) | 58 (46.4) | 58 (23.2) | <.001 |
N1 | 89 (71.2) | 47 (37.6) | 136 (54.4) | ||
N2 | 16 (12.8) | 14 (11.2) | 30 (12.0) | ||
N3 | 20 (16.0) | 6 (4.8) | 26 (10.4) | ||
Ki-67**, at diagnosis | ≤20% | 70 (61.9) | 56 (46.7) | 126 (54.1) | 0.025 |
>20% | 43 (38.1) | 64 (53.3) | 107 (45.9) | ||
Missing | 12 | 5 | 17 | ||
Pregnancy trimester | 1st trimester | 0 (n.a.) | 23 (18.5) | 23 (18.5) | n.a. |
2nd trimester | 0 (n.a.) | 43 (34.7) | 43 (34.7) | ||
3rd trimester | 0 (n.a.) | 58 (46.8) | 58 (46.8) | ||
Missing | 125 | 1*** | 126 |
