Table 1 Clinicopathological features of the entire cohort stratified by response to NACI (pathologic complete response versus non-pathologic complete response)
Characteristic | pCR N = 7a | Residual Disease N = 25a | p-valueb |
|---|---|---|---|
Ethnicity | > 0.9 | ||
Hispanic or Latino | 0 (0%) | 2 (8.0%) | |
Not Hispanic or Latino | 7 (100%) | 23 (92%) | |
Race | 0.2 | ||
Asian | 0 (0%) | 3 (12%) | |
Black | 4 (57%) | 5 (20%) | |
White | 3 (43%) | 17 (68%) | |
Menopausal Status | 0.6 | ||
Post | 4 (57%) | 18 (72%) | |
Pre | 3 (43%) | 7 (28%) | |
Age at diagnosis | 0.8 | ||
Median (IQR) | 52 (48, 63) | 57 (50, 62) | |
[Range] | [33, 85] | [26, 83] | |
Nuclear Grade | > 0.9 | ||
II | 0 (0%) | 2 (8.0%) | |
III | 7 (100%) | 23 (92%) | |
Metaplastic Subtype | 0.5 | ||
Chondromyxoid/Matrix-Producing | 4 (57%) | 9 (36%) | |
Mixed | 2 (29%) | 4 (16%) | |
Spindle | 0 (0%) | 3 (12%) | |
Squamous | 1 (14%) | 9 (36%) | |
Clinical Stage | 0.4 | ||
I | 0 (0%) | 4 (16%) | |
II | 7 (100%) | 18 (72%) | |
III | 0 (0%) | 3 (12%) | |
T stage at diagnosis | 0.6 | ||
T1c | 2 (29%) | 4 (16%) | |
T2 | 5 (71%) | 18 (72%) | |
T3 | 0 (0%) | 3 (12%) | |
N stage at diagnosis | 0.10 | ||
N0 | 4 (57%) | 22 (88%) | |
N1-N2 | 3 (43%) | 3 (12%) | |
Ki-67 (cutoff) | > 0.9 | ||
< 35 | 1 (50%) | 4 (29%) | |
≥ 35 | 1 (50%) | 10 (71%) | |
Unknown | 5 | 11 | |
Completed NACI | 0.4 | ||
No | 3 (43%) | 17 (68%) | |
Yes | 4 (57%) | 8 (32%) | |
Order of NACI first | 0.6 | ||
AC | 1 (14%) | 8 (32%) | |
Carbo | 6 (86%) | 17 (68%) | |
RCB Status | |||
RCB-I | NA | 1 | |
RCB-II | NA | 20 | |
RCB-III | NA | 4 | |
PD-L1 CPS (cutoff - 10) | 0.13 | ||
< 10 | 0 (0%) | 5 (38%) | |
≥ 10 | 6 (100%) | 8 (62%) | |
Unknown | 1 | 12 | |
PD-L1 CPS (cutoff - 1) | > 0.9 | ||
< 1 | 0 (0%) | 1 (7.7%) | |
≥ 1 | 6 (100%) | 12 (92%) | |
Unknown | 1 | 12 | |
sTIL (cutoff - 20) | 0.3 | ||
< 20% | 0 (0%) | 4 (31%) | |
≥ 20% | 6 (100%) | 9 (69%) | |
Unknown | 1 | 12 | |
sTIL (cutoff - 30) | 0.3 | ||
< 30% | 1 (17%) | 6 (46%) | |
≥ 30% | 5 (83%) | 7 (54%) | |
Unknown | 1 | 12 | |
sTIL (cutoff - 60) | 0.041 | ||
< 60% | 1 (17%) | 10 (77%) | |
≥ 60% | 5 (83%) | 3 (23%) | |
Unknown | 1 | 12 |
