Table 1 Description of study cohort

From: Polygenic risk score for breast cancer risk prediction in Asian BRCA1 and BRCA2 pathogenic variants carriers

Description

BRCA1 PV carriers

BRCA2 PV carriers

Total

Aff (%)

Unaff (%)

Total

Aff (%)

Unaff (%)

Total, N

604

390 (100.0)

214 (100.0)

785

552 (100.0)

233 (100.0)

Country

 Malaysia

255

126 (32.3)

129 (60.3)

220

143 (25.9)

77 (33.0)

 Korea

218

159 (40.8)

59 (27.6)

359

229 (41.5)

130 (55.8)

 Hong Kong

67

52 (13.3)

15 (7.0)

93

74 (13.4)

19 (8.2)

 Singapore

64

53 (13.6)

11 (5.1)

113

106 (19.2)

7 (3.0)

Year of Birth

 ≤1940

15

6 (1.5)

9 (4.2)

16

15 (2.7)

1 (0.4)

 1941-1950

40

22 (5.6)

18 (8.4)

71

58 (10.5)

13 (5.6)

 1951-1960

127

86 (22.1)

41 (19.2)

193

140 (25.4)

53 (22.7)

 1961-1970

172

118 (30.3)

54 (25.2)

256

189 (34.2)

67 (28.8)

 >1970

250

158 (40.5)

92 (43.0

249

150 (27.2)

99 (42.5)

Censoring age

 Mean (SD)

42.9 (12.0)

40.9 (10.2)

46.5 (13.9)

44.1 (11.4)

44.3 (10.2)

43.4 (13.8)

 Range

19.13-80.91

19.73–73.63

19.13–80.91

19.19–80.94

22.74–77.77

19.19–80.94

Censoring age group

 ≤30

74

45 (11.5)

29 (13.6)

71

25 (4.5)

46 (19.7)

 30-40

211

165 (42.3)

46 (21.5)

239

191 (34.6)

48 (20.6)

 40-50

163

108 (27.7)

55 (25.7)

245

184 (33.3)

61 (26.2)

 50-60

94

51 (13.1)

43 (20.1)

159

110 (19.9)

49 (21.0)

 >60

62

21 (5.4)

41 (19.2)

71

42 (7.6)

29 (12.4)

  1. Aff Affected, Unaff Unaffected, SD Standard deviation.