Table 2 Association of PRSs with BC risk in BRCA carriers

From: Polygenic risk score for breast cancer risk prediction in Asian BRCA1 and BRCA2 pathogenic variants carriers

PRS

BRCA1 PV carriers (390 affected; 214 unaffected)

BRCA2 PV carriers (552 affected; 233 unaffected)

HR (95% CI)

p-value

HR (95% CI)

p-value

Asian PRS

PRS333

1.15 (0.97–1.36)

0.1046

1.04 (0.88–1.22)

0.6755

PRSGWS

1.47 (1.10–1.95)

0.0089

1.43 (1.04–1.95)

0.0255

European PRS

PRSOVERALL

1.16 (0.98–1.37)

0.0761

1.09 (0.92–1.28)

0.3343

PRSER+

1.16 (0.98–1.38)

0.0862

1.10 (0.92–1.30)

0.3042

PRSER-

1.12 (0.95–1.32)

0.1905

1.07 (0.89–1.29)

0.4738

  1. Analysis was conducted using weighted Cox regression, with the weights estimated based on the average breast cancer incidence among BRCA carriers in four countries. Aff Affected, Unaff Unaffected.
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