Table 3 Proportion of samples in percentile categories of PRSGW and their associations with breast cancer risk

From: Polygenic risk score for breast cancer risk prediction in Asian BRCA1 and BRCA2 pathogenic variants carriers

Percentile

BRCA1 PV carrier

BRCA2 PV carriers

Unaff.

Aff.

Estimated HR (95% CI)

Predicted HR

Unaff.

Aff.

Estimated HR (95% CI)

Predicted HR

0-20

44

57

0.89 (0.52–1.52)

0.59

48

62

0.44 (0.24–0.80)

0.61

20-40

43

42

0.61 (0.34–1.07)

0.82

47

91

0.91 (0.53–1.59)

0.83

40-60

43

72

1

1

47

109

1

1

60-80

43

102

1.57 (0.96–2.55)

1.23

47

136

1.22 (0.73–2.04)

1.21

80-100

44

121

1.57 (0.99–2.49)

1.23

47

155

1.09 (0.67–1.80)

1.67

  1. Aff Affected, Unaff Unaffected.
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