Table 2 Description and values of optimum nanoparticle treatment parameters.
From: Evolutionary computational platform for the automatic discovery of nanocarriers for cancer treatment
Symbol | Description | Unit | Range | Homogeneous | Heterogeneous | |||
|---|---|---|---|---|---|---|---|---|
Solution 1 | Solution 1 | Solution 2 | ||||||
NP1 | NP1 | NP2 | NP1 | NP2 | ||||
D | Diffusion coefficient | cm2/s | [10–8, 10–6] | 1 × 10−6 | 9.8 × 10−7 | 6.4 × 10−7 | 9.7 × 10−9 | 5.7 × 10−7 |
ka | Binding affinity | 1/Ms | [103, 106] | 700,000 | 217,000 | 117,000 | 8300 | 791,000 |
NP0 | Nanoparticle concentration | Molecules | [104, 106] | 60,000 | 923,000 | 150,000 | 236,000 | 828,000 |
E | Number of drug molecules per nanoparticle | Molecules | [102, 104] | 5000 | 400 | 2500 | 7600 | 1200 |
ID | Dosage | mg/kg | [0.025, 55a] | 7.8 | 9.4 | 9.0 | 46.4 | 25.9 |
r | Nanoparticle radius | nm | 2.5 | 2.5 | 4.0 | 264 | 4.5 | |
