Fig. 3

Genetic variation landscape of the tumour sample. a 8169 somatic variants, mostly C to T transitions, identified when comparing the tumour and margin samples. b The 5′ and 3′ nucleotide context around the somatic variants in tumour suggests that most mutations occur in CpG sites. c At the top, genomic location of CNVs: polyploid regions (Gain) in red, diploid regions (Ref) in black, haploid regions (Loss) in green, and loss of heterozygosity (LOH) in blue. In the middle, B-allele ratio plot. At the bottom, genomic translocations (blue) and inversions (purple) in the tumour