Fig. 2
Landscape of copy number alterations in meningioma. a Heatmap of gains (red) and losses (blue) across the genome (y-axis) for 56 samples (x-axis) with whole exome or WGS. Pathological features, primary or recurrent status, and exposure to distant (radiation-induced) or recent adjuvant radiation are annotated. b Percent genome disrupted (y-axis) for low-grade and high-grade meningiomas, as compared with eight other cancers (x-axis). c Percent incidence (x-axis) of chromosome arm-level gains and losses (y-axis). d Percent of genome disrupted (y-axis) for meningiomas stratified by radiation exposure (x-axis). e Percent of genome disrupted (y-axis) for meningiomas stratified by NF2 mutation or chromosome 22 loss (x-axis); angiomatous meningiomas were excluded due to their markedly different genomic profile. AML acute myeloid leukemia, Lg meningioma low-grade meningioma, Hg meningioma high-grade meningioma, GBM glioblastoma, n.s. not significant. Error bars and central values represent mean with s.e.m
