Fig. 3

Characteristics of meningioma rearrangements. a Representative Circos plots for three samples (MEN0042, MEN0011, MEN0053), with lines between genomic coordinates representing intrachromosomal (orange) or interchromosomal (blue) rearrangements. b Example of a complex event involving multiple genomic positions (x-axis) with associated changes in read coverage (y-axis). c Number of rearrangements (y-axis) per sample (x-axis) broken down by complex (orange) or simple (blue) event type. d Circos plot of a hyper-rearranged grade III meningioma and the deconstruction of complex and simple rearrangements to the overall makeup of this sample. e Percent incidence of different mechanisms driving rearrangement formation (y-axis) across multiple cancer types (x-axis). MMEJ micro-homology-mediated end joining, NHEJ non-homologous end joining, MMBIR micro-homology-mediated break-induced repair