Fig. 3 | npj Genomic Medicine

Fig. 3

From: Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies

Fig. 3

Validity of the CDMV hypothesis. a Reference interval distributions in monocytes. The reference interval distribution for the ~24 million CpG sites included in our comprehensive profiles is indicated in grey. The reference interval distribution for CpG sites probed by HumanMethylation450 (HM450) is shown in purple. The reference interval distribution for CpG sites previously reported by blood-based EWASs is represented in magenta. b OR in monocytes. CpG sites probed by HM450 are categorized into ten groups according to reference interval deciles. The OR was estimated by comparing biomarker likelihood for each group of CpG sites with that for all CpG sites probed by HM450 (average biomarker likelihood). Labels in the x-axis represent ranges of DNAm levels as a percentage for each decile. The 95% CIs are shown as solid lines. c Reference interval distributions in CD4+ T cells. d OR in CD4+ T cells

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