Fig. 2

Germline variants are predominantly found in genes involved in DNA checkpoint and repair pathways. a Distribution of molecular pathways among the 121 identified pathogenic or likely pathogenic variants. b For each of the selected cancer types; colorectal cancer, breast cancer, pancreatic cancer, mesothelioma, ovarian cancer, and cervical cancer, the distribution of molecular pathways are shown. The mutated genes are indicated in the figure. Full information about each variant is found in Supplementary Table 4. The number of patients for each cancer type is shown in bracket