Fig. 1: Manhattan plots for a series of genome-wide association studies (GWAS) of statin-induced low-density lipoprotein cholesterol (LDL-C) response, highlighting key chromosomal regions. | npj Genomic Medicine

Fig. 1: Manhattan plots for a series of genome-wide association studies (GWAS) of statin-induced low-density lipoprotein cholesterol (LDL-C) response, highlighting key chromosomal regions.

From: The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change

Fig. 1

A GWAS for baseline-adjusted difference of natural log-transformed LDL-C levels yielded six significant loci (a), whereas a GWAS of baseline-unadjusted statin-induced percent LDL-C lowering yielded three loci that met genome-wide significance (b). Consistent with the impact of baseline-adjustment on results, baseline-unadjusted difference of natural log-transformed LDL-C levels (c) and baseline-adjusted statin-induced percent LDL-C lowering (d) yielded three and six genome-wide significant loci, respectively. All tests were two-sided.

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