Table 2 Some insights into human biology from initiatives prioritizing inclusion of participants of African ancestry.
From: Evaluating the promise of inclusion of African ancestry populations in genomics
Initiative | Novel loci and novel associations within known locia |
|---|---|
Trans-Omics for Precision Medicine (TOPMed) | Serum lipids111 Lipoprotein(a)112 Chronic obstructive pulmonary disease113 Rh antigens114 |
Population Architecture using Genomics and Epidemiology II (PAGE II) study | Serum lipids118 Glycemic traits119 QT interval120 Age of reproductive events among women121 C-reactive protein122 Blood pressure123 Complex traits107 |
The Million Veteran’s Program (MVP) | Serum lipids124 Blood pressure108 |
CHARGE Gene–Lifestyle Interactions125 | |
The Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) | Understanding of genetic diversity among individuals with African ancestry131,132 asthma risk133 |
MalariaGEN | Severe malaria risk134 Cerebral malaria and alphathalassemia135 Malaria resistance136 G6PD and malaria risk137 |