Table 2 Some insights into human biology from initiatives prioritizing inclusion of participants of African ancestry.

From: Evaluating the promise of inclusion of African ancestry populations in genomics

Initiative

Novel loci and novel associations within known locia

Trans-Omics for Precision Medicine (TOPMed)

Serum lipids111

Lipoprotein(a)112

Chronic obstructive pulmonary disease113

Rh antigens114

Population Architecture using Genomics and Epidemiology II (PAGE II) study

Adiposity traits115,116,117

Serum lipids118

Glycemic traits119

QT interval120

Age of reproductive events among women121

C-reactive protein122

Blood pressure123

Complex traits107

The Million Veteran’s Program (MVP)

Serum lipids124

Blood pressure108

CHARGE Gene–Lifestyle Interactions125

Blood pressure109,126,127

Serum lipids128,129,130

The Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA)

Understanding of genetic diversity among individuals with African ancestry131,132

asthma risk133

MalariaGEN

Severe malaria risk134

Cerebral malaria and alphathalassemia135

Malaria resistance136

G6PD and malaria risk137

Population genetics138,139

  1. aIncluding novel loci for the studied trait as well as novel associations within known loci