Table 1 DNA methylation sites significantly associated with ALS at p < 3.1 × 10−7 from MOA and MOMENT in the Australian cohort.

From: Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis

Chr

Probe

bp

Gene

Orientation

b_MOA

p_MOA

b_MOMENT

p_MOMENT

4

cg08422863

88379498

HERC6

R

−0.16

5.9 × 10−9

−0.07

0.01

13

cg05380910

38989909

STOML3

F

0.15

9.8 × 10−9

0.06

0.04

3

cg24866706

96619630

RPL18AP8;MTRNR2L12

R

0.15

2.1 × 10−8

0.04

0.09

3

cg27143246

169771795

MYNN;RP11−816J6.3

R

−0.15

2.4 × 10−8

−0.05

0.07

12

cg00178984

59697390

SLC16A7

R

0.15

5.8 × 10−8

0.06

0.02

8

cg26078251

124300968

RP11-383J24.2

F

0.15

6.5 × 10−8

0.05

0.06

8

cg20134271

124483581

RNF139

R

0.15

8.2 × 10−8

0.04

0.13

7

cg05303559

158719689

AC019084.7

F

0.14

1.5 × 10−7

0.03

0.35

5

cg04104695

139679164

CXXC5

R

−0.14

2.7 × 10−7

−0.14

2.1 × 10−7

6

cg12785183

166031972

—

F

0.14

2.7 × 10−7

0.01

0.9

11

cg21836562

128868867

KCNJ1

R

0.14

2.9 × 10−7

0.05

0.08

11

cg07613278

43311777

API5

F

−0.14

3 × 10−7

−0.03

0.2

  1. Chr chromosome number, Probe probe identification number as provided by Illumina, bp base pair position in the genome, Gene closest genes the probe is annotated to, based on distance to transcription starting site, following the method described elsewhere,44 Orientation DNA strand orientation, F forward, R Reverse, b_MOA effects sizes (increase (positive sign) or decrease (negative sign) of methylation between cases and controls per standard deviation unit) of AU MOA, p_MOA ps of MOA models for AU, b_MOMENT effects sizes (interpreted as b_MOA) of AU MOMENT, p_MOMENT ps of AU MOMENT.
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