Fig. 1: The definition of the IMS genes. | npj Genomic Medicine

Fig. 1: The definition of the IMS genes.

From: Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma

Fig. 1

A–C Volcano plot depiction of differentially expressed genes after normalization by the IFN-γ score of individual sample by response on Riaz17 (in A, n = 51), Gide19 (in B, n = 41) and Hugo16 (in C, n = 28). R, responders (CR or PR); NR, nonresponders (PD) as per RECIST 1.1. IMS genes are highlighted in red. D Heatmap showing the expression of genes from the IFN-γ signature and the IMS stratified by IFN-γ and response to anti-PD-1 therapy. Rows represent genes and columns represent patients. The expression levels were z-normalized within rows for visualization. The cutoff value for the IFN-γ signature score was set to its median. The IMS scores in responders versus nonresponders for IFN-γ+ (E) and IFN-γ− (F) subgroups.

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