Fig. 2: Association of IMS with abundance of immune cell types in TME. | npj Genomic Medicine

Fig. 2: Association of IMS with abundance of immune cell types in TME.

From: Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma

Fig. 2

A, B Heatmap showing the Pearson correlation of selected immune cell types with IMS scores (in A) and IFN-γ (in B) in combined melanoma cohorts consisting of all samples from the discovery cohort and TCGA melanoma dataset (n = 516). Fibroblasts showed the strongest association with the IMS score (Pearson correlation r = 0.62, p < 0.001), followed by M1 macrophage (r = 0.50, p < 0.001), monocytes (r = 0.45, p < 0.001) and macrophage (r = 0.35, p < 0.001). On the other hand, CD8+ T cell showed the strongest association with the IFN-γ score (r = 0.61, p < 0.0001). C, Violin plot showing the cell type distributions estimated using xCell for 4 groups of patients with IFN-γ+/IMS+(n = 183), IFN-γ+/IMS− (n = 75), IFN-γ-/IMS+ (n = 75), IFG-γ-/IMS− (n = 183) in the combined melanoma cohort. Cutoff values for the IFN-γ signature and IMS scores were set to their median in all the data.

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