Fig. 5: Ratio of IFN-γ signature to IMS predicts response to ICI immunotherapy on the PUCH cohort. | npj Genomic Medicine

Fig. 5: Ratio of IFN-γ signature to IMS predicts response to ICI immunotherapy on the PUCH cohort.

From: Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma

Fig. 5

A The ORR of patients from IFN-γ/IMS-high versus IFN-γ/IMS-low and B IFN-γ-high versus IFN-γ-low on the PUCH cohort. The cutoff points were decided by the Youden index for IFN-γ/IMS and IFN-γ scores, respectively. C IFN-γ signature and IMS scores of individual patients in the PUCH cohort. The red and blue dashed lines indicate the cutoff points for IFN-γ/IMS ratio and IFN-γ, respectively. Red circles indicate nonresponse patients who were misclassified by IFN-γ signature and correctly classified by IFN-γ/IMS ratio. D Kaplan–Meier plots of OS segregated by IFN-γ/IMS ratio with cutoff points selected according to the Youden index. E ROC curve of the sensitivity versus 1-specificity of the predictive performance of IFN-γ/IMS. Patients with SD were not included in AUC calculation. F Comparison of the AUC of IFN-γ/IMS with nine GEP signatures (Table 1) in predicting response to ICI.

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