Fig. 6: Ratio of IFN-γ signature to IMS predicts response to ICI immunotherapy on published datasets. | npj Genomic Medicine

Fig. 6: Ratio of IFN-γ signature to IMS predicts response to ICI immunotherapy on published datasets.

From: Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma

Fig. 6

A–C ROC curve of the sensitivity versus 1-specificity of the predictive performance of IFN-γ/IMS. Patients with SD were not included in AUC calculation. D–F Comparison of the AUC of IFN-γ/IMS with nine GEP signatures (Table 1) in predicting response to ICI. G, H Kaplan–Meier plots of OS segregated by IFN-γ/IMS ratio with cutoff values selected according to the Youden index identified in individual datasets. Kaplan–Meier plot for Kim19 was not generated due to unavailability of survival data for this dataset.

Back to article page