Table 1 Demographics of the total ONDRI cohorts and cognitively normal control cohort at baseline and the demographics of the cohorts following multivariate outlier analysis.

From: Contribution of rare variant associations to neurodegenerative disease presentation

Cohort

Total participants

Ancestry-matched participants

Samples

Mean age (years ± s.d.)

Male:Female

Samples

Mean age (years ± s.d.)

Male:Female

ONDRI

519

68.6 ± 7.6

341:172

396

68.7 ± 7.9

268:128

AD

41

71.8 ± 8.0

24:17

33

71.4 ± 7.9

19:14

ALS

40

62.0 ± 8.7

24:16

32

61.9 ± 9.2

23:9

CVD

161

69.2 ± 7.4

109:50

124

69.6 ± 7.6

87:37

FTD

53

67.8 ± 7.1

34:19

39

67.5 ± 7.3

25:14

MCI

85

70.6 ± 8.3

45:40

59

71.9 ± 8.3

29:30

PD

139

67.8 ± 6.4

106:30

109

67.5 ± 6.3

85:24

Controls

189

74.0 ± 8.2

77:112

164

74.0 ± 7.9

68:96

  1. The common variation (MAF > 0.005) captured by the ONDRISeq next-generation sequencing panel was used to perform principal component analysis on the ONDRI cases and controls accounting for variance introduced by differential ancestry and batch effects. Multivariate outlier analysis was performed using the first eight principal components. Ancestry matched refers to all samples that were not removed by the outlier analysis. Abbreviations: AD Alzheimer’s disease, ALS amyotrophic lateral sclerosis, CVD cerebrovascular disease, FTD frontotemporal dementia, MCI mild cognitive impairment, ONDRI Ontario Neurodegenerative Disease Research Initiative, PD Parkinson’s disease, s.d. standard deviation.
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