Fig. 3: Warfarin dosing prediction. | npj Genomic Medicine

Fig. 3: Warfarin dosing prediction.

From: A population study of clinically actionable genetic variation affecting drug response from the Middle East

Fig. 3

Distribution of the predicted weekly dose (mg) of warfarin in the Qatari population (yellow) using the IWPC algorithm based on age, sex, height, weight, ethnicity, the concurrent use of drugs that decrease warfarin requirements, and the genotypes/diplotypes of VKORC1 and CYP2C9. Also shown is the distribution of dosage in patients of European ethnicity from the EU-PACT trial (blue). Weekly doses in mg are plotted in the Y-axis for the two populations. The box is drawn with the interquartile range and the central horizontal line showing the median, while values above the range shown as whiskers. Individuals with values ≤21 mg per week (below the bottom horizontal line) would be predicted to need a lower dose, and those with values ≥49 mg per week (above the top horizontal line) would be predicted to need a higher dose.

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