Fig. 4: Locus zoom plot showing the relationship of rs79727797 association with residual age at onset to that of the sum of two quasi-tandem repeat (QTR) lengths (black cross) in 468 subjects with both single nucleotide variant (SNV) and sequencing data. | npj Genomic Medicine

Fig. 4: Locus zoom plot showing the relationship of rs79727797 association with residual age at onset to that of the sum of two quasi-tandem repeat (QTR) lengths (black cross) in 468 subjects with both single nucleotide variant (SNV) and sequencing data.

From: Huntington’s disease age at motor onset is modified by the tandem hexamer repeat in TCERG1

Fig. 4

The associations of age at onset with the sum of STR (red cross) and QTR (blue cross) repeat lengths in all 610 subjects are also shown. The bar on the right of the plot indicates the strength of linkage disequilibrium (r2) between each SNV and the tandem repeat. The p-value threshold for genome-wide significance (5 × 10−8) is shown with a black dashed line.

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