Fig. 3: Effects of ET drugs on common and rare variants. | npj Genomic Medicine

Fig. 3: Effects of ET drugs on common and rare variants.

From: Transcriptomic effects of propranolol and primidone converge on molecular pathways relevant to essential tremor

Fig. 3

a Correlation heatmap of ET TWAS gene Z-scores in different brain tissues and drug effect gene Z-scores from different meta-analysis conditions. Values indicate Z-score regression coefficient from linear model. b Correlation plot of TWAS gene Z-scores from cerebellar tissue and convergent primidone and propranolol gene Z-scores across DAOYs and NPCs. c Line histogram displaying the distribution of O/E LOEUF scores from all protein coding genes (blue) and convergent DEGs (red) following drug treatment. O/E scores were directly transformed to percentages (ex. 0.25 as 25%) with scores over 10 counted as 100%. d Violin plots of O/E LOEUF scores for upregulated DEGs (yellow), downregulated DEGs (red) and non-significant DEGs (green). Boxplot elements: center line = median; upper and lower hinges = 1st and 3rd quartiles respectively; whiskers = mean ± interquartile range × 1.5.

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