Fig. 1: Residue network score correlates with mutation intolerance and distinguishes pathogenic variants from benign variants in well-studied human proteins. | npj Genomic Medicine

Fig. 1: Residue network score correlates with mutation intolerance and distinguishes pathogenic variants from benign variants in well-studied human proteins.

From: Structure-based network analysis predicts pathogenic variants in human proteins associated with inherited retinal disease

Fig. 1

a Structural representations show network scores at each residue. Sphere radius and color corresponds to network score magnitude at a particular position. b Comparison between functional data from saturation mutagenesis experiments and network scores, with Spearman correlation coefficients and p-values displayed for each plot. Points are colored based on available clinical phenotype data. c Pooled comparison between network scores for variants with available clinical phenotype data for all four well-studied human proteins. d Individual comparisons between network scores for variants with available clinical phenotype data for all four well-studied human proteins.

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