Fig. 3: Comparison of effect sizes for white matter lesions between JPSC-AD and UK Biobank. | npj Genomic Medicine

Fig. 3: Comparison of effect sizes for white matter lesions between JPSC-AD and UK Biobank.

From: Common protein-altering variant in GFAP is associated with white matter lesions in the older Japanese population

Fig. 3

The plot shows the effect sizes of the lead variants of the 20 signals that met the genome-wide significance level (5.0 × 10−8) in the GWAS meta-analysis. The horizontal axis indicates the beta values in the UK Biobank and the vertical axis denotes the effect sizes in the JPSC-AD GWAS. Nineteen of the 20 variants have concordant positive and negative beta values, with a sign test of P < 0.001. The plots are colored according to their associations in the JPSC-AD GWAS.

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