Table 1 Lead variants of the genome-wide significant loci for white matter hyperintensity lesion volume, the JPSC-AD Study

From: Common protein-altering variant in GFAP is associated with white matter lesions in the older Japanese population

Chr:Pos

Location

Lead variant

Ref/Alt

Nearest gene

Annotation

EAF

β (SE)

P

JPSC-AD

EUR (1KGP)

10:105591049

10q24.33

rs11191817

T/C

SH3PXD2A

Intronic

0.444

0.055

−0.080 (0.015)

2.80E-08

17:42989063

17q21.31

rs1126642

C/T

GFAP

Exonic / Missense variant

0.151

0.030

−0.151 (0.020)

1.10E-13

17:73874071

17q25.1

rs4600514

G/A

TRIM47

Exonic / Missense variant

0.107

0.165

0.189 (0.023)

8.00E-16

  1. Chr chromosome, Pos position, Ref reference allele, Alt alternative allele, EAF effect allele frequency, GWAS genome-wide association study, EUR (1KGP) European population of the 1000 Genomes Project, SE standard error.
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