Fig. 5: Expansion of γδ T cells.
From: Pre-T cell receptor-α immunodeficiency detected exclusively using whole genome sequencing
A Vδ1+ and Vδ1-Vδ2- γδ T cell populations were expanded in the patient. B Patient CD4-CD8- DN Vδ1+ and Vδ1-Vδ2- populations demonstrate a primarily naive phenotype, while CD8lo/int subsets are mostly CD28-CD45RA+. Patient Vδ2+ cells appear antigen-experienced like normal controls. C CXCR5 expression on control and patient γδ T cells. D CXCR5 is selectively expressed by a subset of the Vδ1+ and Vδ1-Vδ2- γδ T cell populations.
