Table 2 Top 20 significant hits from the sex-combined cross-ancestry PheWAS meta-analysis of EUR, AFR, EAS, HIS
From: Insights from the largest diverse ancestry sex-specific disease map for genetically predicted height
phecode | Description | Category | OR | Lower | Upper | P-value | pval het |
|---|---|---|---|---|---|---|---|
427.2 | Atrial fibrillation and flutter | Circulatory system | 1.16 | 1.15 | 1.17 | 1.08 × 10–226 | 4.50 × 10–4 |
427.21 | Atrial fibrillation | Circulatory system | 1.15 | 1.14 | 1.17 | 1.24 × 10–158 | 1.27 × 10–3 |
454.1 | Varicose veins of lower extremity | Circulatory system | 1.16 | 1.15 | 1.18 | 2.87 × 10–109 | 4.17 × 10–2 |
454 | Varicose veins | Circulatory system | 1.15 | 1.14 | 1.17 | 1.23 × 10–108 | 5.85 × 10–2 |
427 | Cardiac dysrhythmias | Circulatory system | 1.07 | 1.06 | 1.07 | 5.68 × 10–87 | 3.63 × 10–10 |
272.1 | Hyperlipidemia | Endocrine/metabolic | 0.94 | 0.94 | 0.95 | 4.04 × 10–86 | 1.34 × 10–4 |
272 | Disorders of lipoid metabolism | Endocrine/metabolic | 0.94 | 0.94 | 0.95 | 7.13 × 10–86 | 1.28 × 10–4 |
707.2 | Chronic ulcer of leg or foot | Dermatologic | 1.19 | 1.17 | 1.21 | 6.29 × 10–84 | 7.27 × 10–3 |
735.21 | Hammer toe (acquired) | Musculoskeletal | 1.18 | 1.16 | 1.20 | 9.23 × 10–79 | 3.12 × 10–3 |
401.1 | Essential hypertension | Circulatory system | 0.95 | 0.94 | 0.95 | 1.51 × 10–78 | 1.29 × 10–3 |
401 | Hypertension | Circulatory system | 0.95 | 0.94 | 0.95 | 2.20 × 10–77 | 1.31 × 10–3 |
356 | Hereditary and idiopathic peripheral neuropathy | Neurological | 1.15 | 1.13 | 1.16 | 3.71 × 10–74 | 1.21 × 10–1 |
707 | Chronic ulcer of skin | Dermatologic | 1.14 | 1.12 | 1.16 | 1.19 × 10–72 | 1.05 × 10–5 |
286.2 | Encounter for long-term (current) use of anticoagulants | Hematopoietic | 1.13 | 1.12 | 1.15 | 4.40 × 10–71 | 8.36 × 10–4 |
427.22 | Atrial flutter | Circulatory system | 1.17 | 1.15 | 1.19 | 1.96 × 10–69 | 1.18 × 10–1 |
700 | Corns and callosities | Dermatologic | 1.15 | 1.13 | 1.17 | 7.51 × 10–69 | 2.42 × 10–5 |
456 | Chronic venous insufficiency [CVI] | Circulatory system | 1.16 | 1.14 | 1.18 | 2.04 × 10–64 | 6.65 × 10–2 |
411.8 | Other chronic ischemic heart disease, unspecified | Circulatory system | 0.93 | 0.92 | 0.94 | 6.38 × 10–59 | 2.80 × 10–1 |
411 | Ischemic Heart Disease | Circulatory system | 0.95 | 0.94 | 0.95 | 1.03 × 10–56 | 6.53 × 10–3 |
411.4 | Coronary atherosclerosis | Circulatory system | 0.94 | 0.94 | 0.95 | 5.14 × 10–55 | 2.07 × 10–3 |
