Table 1 Baseline demographic data for cohorts included in study
Cohort | UTHealth (ES) | UTHealth (WGS) | Penn Medicine BioBank (ES) | UK Biobank (WGS) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
ESTAD | HTAD | Controls | HTAD | TAA | Dissection | Controls | TAA | TAA with surgery | Dissection | Controls | |
Individuals Sequenced, n | 551 | 437 | 1431 | 97 (from 57 pedigrees) | 1377 | 262 | 41614 | 1084 | 263 | 467 | 447570 |
Age (years), average (range) | 46.4 (19-60) | 51.3 (15-89) | 63.0 (44-81)* | 57.9 (14-87) | 62.5 (20-93) | 61.8 (21-87) | 54.6 (18-103) | 60.3 (40-70) | 59.1 (40-70) | 60.9 (41-70) | 56.7 (38-72) |
Male sex, n (%) | 421 (76.4) | 255 (58.3) | 818 (57.1) | 57 (58.8) | 1039 (75.5) | 176 (67.2) | 20373 (49.0) | 760 (70.1) | 178 (67.7) | 290 (62.1) | 203046 (45.4) |
European ancestry, n (%) | 450 (81.7) | 409 (93.6) | 1224 (85.5) | 97 (100) | 1175 (85.3) | 177 (67.6) | 28599 (68.7) | 1084 (100) | 263 (100) | 467 (100) | 447570 (100) |
Hypertension, n (%) | 470 (85.3) | na | 167 (85.2)* | na | 1071 (77.8) | 245 (93.5) | 22899 (55.0) | 814 (75.1) | 207 (78.7) | 333 (71.3) | 139318 (31.1) |
Dissection, n (%) | 551 (100) | 155 (35.5) | 0 | 19 (19.5) | 0 | 262 (100) | 0 | 0 | 0 | 467 (100) | 0 |
Type A dissection, n (%) | 378 (68.6) | 127 (29.1) | 0 | 18 (18.5) | 0 | na | 0 | 0 | 0 | na | 0 |
Type B dissection, n (%) | 173 (31.4) | 28 (6.4) | 0 | 1 (1) | 0 | na | 0 | 0 | 0 | na | 0 |
P/LP variant, n (%) | 51 (9.3) | 37 (8.5) | 0 | 0 | 38 (2.8) | 31 (11.8) | 0 | 6 (0.5) | 3 (1.1) | 24 (5.1) | 0 |
