Table 1 The pathways co-enriched by the genes and metabolites regulated by µG
From: Gene-metabolite profile integration to understand the cause of spaceflight induced immunodeficiency
Pathway | # of genes | # of metabolites | p-value |
|---|---|---|---|
Arginine and proline metabolism | 10 | 3 | 0.001 |
Urea cycle and metabolism of arginine, proline, glutamate, aspartate, and asparagine | 17 | 3 | 0.001 |
Bile acid biosynthesis | 3 | 2 | 0.009 |
Arginine:glycine amidinotransferase deficiency (AGAT deficiency) | 3 | 2 | 0.025 |
Creatine deficiency; guanidinoacetate methyltransferase deficiency | 3 | 2 | 0.025 |
Guanidinoacetate methyltransferase deficiency (GAMT deficiency) | 3 | 2 | 0.025 |
Hyperornithinemia with gyrate atrophy (HOGA) | 3 | 2 | 0.025 |
Hyperornithinemia hyperammonemia homocitrullinuria [HHH-syndrome] | 3 | 2 | 0.025 |
Hyperprolinemia | 3 | 3 | 0.025 |
