Table 2 Bone mechanical properties following partial weightbearing ± radiation exposure for 21 days (post partial weightbearing) and after 21 additional days to assess long-term response (post recovery)

From: Positive impact of low-dose, high-energy radiation on bone in partial- and/or full-weightbearing mice

 

WB-Sham

WB-Rad

G/6-Sham

G/6-Rad

Post partial weightbearing

Mid-shaft Femur 3-point Bend

 Ultimate load (N)

18.6 ± 2.50

19.8 ± 1.90

19.6 ± 2.50

17.4 ± 2.10

 Stiffness (N/mm)

91.6 ± 2.80

94.7 ± 14.90

101 ± 19.8

97.0 ± 18.3

Femoral neck compression

 Ultimate load (N)

11.2 ± 1.80

11.4 ± 1.30

10.0 ± 1.50

11.1 ± 0.80

 Stiffness (N/mm)

28.9 ± 7.90

30.5 ± 12.2

23.0 ± 7.30

31.4 ± 7.23

Post recovery

Mid-shaft Femur 3-point Bend

 Ultimate load (N)

20.5 ± 1.43

22.1 ± 2.13

21.7 ± 1.70

19.6 ± 1.80

 Stiffness (N/mm)

89.0 ± 8.9

95.4 ± 36.6

79.5 ± 18.5

95.7 ± 26.5

 Energy-to-ultimate (mJ)

3.05 ± 0.63

3.02 ± 0.06

3.32 ± 0.43

3.34 ± 0.92

 Energy-to-fracture (mJ)

6.65 ± 1.60

4.79 ± 0.30

5.20 ± 1.24

4.66 ± 1.74

 Postyield energy (mJ)

5.40 ± 1.73

3.33 ± 0.18

3.84 ± 1.33

3.35 ± 1.61

Femoral neck compression

 Ultimate load (N)

11.1 ± 1.75

12.0 ± 1.82

10.7 ± 1.79

11.4 ± 0.7

 Stiffness (N/mm)

33.8 ± 12.1

25.3 ± 3.85

25.7 ± 6.50

29.1 ± 12.2

  1. Two different mechanical tests are represented following 0.5 Gy 56Fe and/or G/6 for 21 days (Post partial weightbearing) and for separate groups maintained for 21 additional days of full weightbearing recovery (Post recovery). Mid -shaft femurs were subjected to three-point bending to failure and femoral necks to axial compression with quasi-static loading rates. WB weightbearing, Sham no exposure to radiation, Rad acute dose of 0.5 Gy 56Fe, G/6 partial weightbearing. Group means that share the same letter are not statistically different from one another (p < 0.05); pairwise comparisons generated from Kruskal–Wallis ANOVA (data not normally distributed)
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