Table 3 Histomorphometric measures of bone formation following partial weightbearing ± radiation exposure for 21 days (post partial weightbearing) and after 21 additional days to assess long-term response (post recovery)
WB-Sham | WB-Rad | G/6-Sham | G/6-Rad | |
|---|---|---|---|---|
Post partial weightbearing | ||||
Distal femur | ||||
MS/BS (%) | 5.94 ± 4.83 | 13.71 ± 6.28 | 2.61 ± 3.31 | 8.59 ± 3.22 |
Double Label Present | 6 of 6 | 5 of 5 | 6 of 8 | 4 of 4 |
MAR (um/d) | 0.62 ± 0.37 | 0.63 ± 0.41 | 0.14 ± 0.13 | 2.18 ± 2.70 |
BFR (um³/um²/y) | 9.57 ± 8.75 | 37.4 ± 29.1 | 1.07 ± 1.17 | 83.1 ± 107 |
Midshaft tibia | ||||
Endocortical MS/BS (%) | 22.20 ± 13.39 | 23.35 ± 12.89 | 7.30 ± 2.49 | 4.68 ± 5.82 |
Double Label Present | 1 of 4 | 1 of 7 | 0 of 5 | 0 of 7 |
Periosteal MS/BS (%) | 2.24 ± 3.49 | 2.19 ± 2.09 | 1.12 ± 1.6 | 0.79 ± 1.02 |
Double Label Present | 1 of 4 | 0 of 7 | 0 of 5 | 0 of 7 |
Post recovery | ||||
Distal femur | ||||
MS/BS (%) | 16.0 ± 3.49 | 18.9 ± 6.18 | 19.74 ± 9.34 | 15.60 ± 5.60 |
Double Label Present | 4 of 5 | 4 of 4 | 8 of 9 | 7 of 7 |
MAR (um/d) | 1.97 ± 0.74 | 1.50 ± 1.02 | 1.33 ± 0.40 | 0.79 ± 0.49 |
BFR (um³/um²/y) | 85.9 ± 52.1 | 110 ± 89.6 | 78.4 ± 56.8 | 50.3 ± 34.7 |
Midshaft tibia | ||||
Endocortical MS/BS (%) | 14.17 ± 9.49 | 18.07 ± 11.65 | 32.06 ± 15.34 | 37.5 ± 11.1 |
Double Label Present | 3 of 7 | 2 of 6 | 3 of 6 | 4 of 7 |
Periosteal MS/BS (%) | 14.38 ± 7.71 | 6.66 ± 4.2 | 18.61 ± 11.86 | 13.5 ± 7.92 |
Double Label Present | 4 of 7 | 1 of 6 | 3 of 6 | 2 of 7 |
